Product lineup

MMPs, MT-MMPs & TIMPs

Matrix metalloproteinases (MMPs) are a family of Zn2+ -endopeptidases which were believed to be crucial for tumor cell invasion and metastasis, acting by degrading extracellular matrix macromolecules such as type IV collagen. The activity of MMPs is regulated by a family of endogenous inhibitors known as TIMPs. It has been suggested that an imbalance between MMPs and TIMPs triggers for Rheumatoid Arthritis, tumor cell invasion and metastasis.

We can now offer monoclonal antibodies to MMP-1 (interstitial collagenase), MMP-2 (gelatinase A), MMP-3 (stromelysin-1), MMP-7 (matrilysin), MMP-8 (neutrophil collagenase), MMP-9 (gelatinase B) and MT-MMPs (membrane-type matrix metalloproteinases) for immunoblotting and immunohistochemistry and their EIA kits for determination of levels in blood, urine and body fluids. We can also offer recombinant TIMP-1 and TIMP-2.

Monoclonal Antibodies : MMPs,MT-MMPs and TIMPs

(Markers of Cancer Invasionand Metastasis,Rheumatoid Arthritis and Osteoarthrisis)

No. Product Antigen Isotype Clone Appli-cation Spe-cies Epitope
F-67 Anti-HumanMMP-1 Peptide**(R 332-350) Mouse MAb
IgG2a/kappa
41-
1E5
WB,
PS, FS
H, Rb C-Terminaldomain
F-91 Anti-activeHuman MMP-1 Peptide**(FVLTEGN,R81-87) Mouse MAb
IgG2b/kappa
195-
1H6
WB H N-Terminaldomain
F-68 Anti-HumanMMP-2 Peptide**(R 468-483) Mouse MAb
IgG1/kappa
42-
5D11
WB,
PS, FS
H. rB,
M, Rb
C-Terminaldomain
F-73 Anti-HumanMMP-2 Human Skinfibroblasts Mouse MAb
IgG1/kappa
75-
7F7
EIA,
WB,PS,
FS
H, B,
M
Latent (72kDa)andactive
(67kDa)forms
F-66 Anti-HumanMMP-3 Humansynovialcells Mouse MAb
IgG1/kappa
55-
2A4
EIA,
WB,
FS,PS
H, r,
S, P
Latent(57,59kDa)and
active(45, 28kDa)forms
F-77 Anti-RabbitMMP-3 Rabbituterinecervicalfibroblasts Mouse MAb
IgG1/kappa
148-
1A3
EIA,
WB,
PS
Rb Latent(51kDa)andactive
(39, 35,27, 25kDa)forms
F-82 Anti-HumanMMP-7 Humanrectalcarcinomacells Mouse MAb
IgG1/kappa
141-
7B2
WB,
PS
H Latentform(28kDa)
F-90 Anti-activeHuman MMP-7 Peptide**(YSLFP,R78-82) Mouse MAb
IgG1/kappa
176-
5F12
WB H N-Terminaldomain
F-83 Anti-HumanMMP-8 Human neutrophicollagenase Mouse MAb
IgG1/kappa
115-
13D2
WB,
PS
H Latent(85kDa)
andactive(64kDa)forms
F-69 Anti-HumanMMP-9 Peptide**(R 626-644) Mouse MAb
IgG1/kappa
56-
2A4
WB,PS,
FS
H, Gr,
Rb
C-Terminaldomain
F-93 Anti-HumanMMP10 Peptide**(R250-268) Mouse MAb
IgG1/kappa
142-
9B11
WB H Hingedomain
F-89 Anti-HumanMMP-13 Recombinanthuman MMP-13 Mouse MAb
IgG1/kappa
181-
15A12
EIA,
WB,
PS
H Latent(60kDa)
andactive(48kDa)forms
F-94 Anti-HumanMMP-13 Recombinanthuman MMP-13 Mouse MAb
IgG1/kappa
181-
14G11
WB,
PS
H Latent(60kDa)
andactive(48kDa)forms
F-102 Anti-HumanMMP-20 Peptide*(R 430-445) Mouse MAb
IgG1/kappa
203-
1C7
WB,
PS
H, P C-Terminaldomain
F-80 Anti-HumanMT1-MMP Peptide*(R 160-173) Mouse MAb
IgG1/kappa
114-
1F2
WB,
IP
H Catalyticdomain
F-84 Anti-HumanMT1-MMP Peptide*(R 319-333) Mouse MAb
IgG3/kappa
113-
5B7
WB,
PS,
IP
H,r,
PRb,
M
Hemopexin-likedomain
F-86 Anti-HumanMT1-MMP Peptide*(R 160-173) Mouse MAb
IgG1/kappa
114-
6G6
WB,
PS
H Catalyticdomain
F-88 Anti-MouseMT2-MMP Peptide*(R 281-294) Mouse MAb
IgG1/kappa
162-
22G5
WB,
PS
H, M Catalyticdomain
F-81 Anti-HumanMT3-MMP Peptide*(R 168-181) Mouse MAb
IgG1/kappa
117-
10C6
WB,
PS
H Catalyticdomain
F-23 Anti-BovineTIMP-1 Bovinedentalpulps Mouse MAb
IgG1/kappa
7-
6C1
EIA,
WB, PS
H,B,
r
-
F-26 Anti-HumanTIMP-1 Recombinanthuman TIMP-1 Mouse MAb
IgG1/kappa
147-
6D11
WB, PS H -
F-70 Anti-HumanTIMP-2 Peptide***(R 178-193) Mouse MAb
IgG1/kappa
67-
4H11
WB,PS,
FS
H, Rb,
r, M,
B, G
C-Terminaldomain
F-85 Anti-HumanTIMP-3 Peptide***(R 170-188) Mouse MAb
IgG1/kappa
136-
13H4
WB,
FS, PS
H, Rb C-Terminaldomain
F-87 Anti-MouseMT2-MMP Peptide*(R 281-294) Mouse MAb
IgG2b/kappa
162-
4E3
WB H, M Catalyticdomain
F-109 Anti-HumanTIMP-4 Recombinanthuman TIMP-4 Mouse MAb
IgG2b/kappa
216-
1G2
WB H
F-110 Anti-HumanTIMP-4 Recombinanthuman TIMP-4 Mouse MAb
IgG2b/kappa
216-
2C9
WB H

***:numbered from N-terminal of mature form. R:residue

EIA : Enzyme Immunoassay, WB : Western Blot, IP : Immunoprecipitation

Immunohistochemistry (FS:Frozen Section, PS:Paraffin Section)

Cross-reaction (H:Human, B:Bovine, Rb:Rabbit, r:rat, M:Mouse, G:Guinea pig, S:Sheep, P:Pig )