Product lineup

Cathepsins

Cathepsins, the lysosomal proteinases, are distributed in normal tissues and expressed in a variety of physiological and pathophysiological processes such as bone resorption, muscular dystrophy, arthritis and tumor invasion and metastasis.
They are synthesized as proenzymes which are processed to the active form by removal of proregion.
Mature cathepsins are localized in the lysosomes where they function in protein turnover but have also been shown to be capable of degrading ECM proteins. Higher levels of several cathepsins have been associated with thepathological destruction of the ECM leading to tumor metastasis, osteoporosis and rheumatoid arthritis.

Monoclonal Antibodies : Cathepsins

No. Product Antigen Isotype Clone Appli-cation Spe-cies Epitope
F-92 Anti-Human
Cathepsin K
Peptide**
(R182-195)
Mouse MAb
IgG1/kappa
182-
12G5
WB H -
F-103 Anti-Human
Cathepsin F
Recombinant
human Cathepsin F
Mouse MAb
IgG1/kappa
233-3D4 WB H -
F-104 Anti-Human
Cathepsin F
Recombinant
human Cathepsin F
Mouse MAb
IgG1/kappa
233-13D2 WB H -
F-105 Anti-Human
Cathepsin L2
Recombinant
human Cathepsin L2
Mouse MAb
IgG2a/kappa
236-2D8 WB H -
F-106 Anti-Human
Cathepsin L2
Recombinant
human Cathepsin L2
Mouse MAb
IgG2b/kappa
236-8C9 WB H -
F-107 Anti-Human
Cathepsin Z
Recombinant
human Cathepsin Z
Mouse MAb
IgG1/kappa
237-2D10 WB H -
F-108 Anti-Human
Cathepsin Z
Recombinant
human Cathepsin Z
Mouse MAb
IgG1/kappa
237-11B4 WB H -

***:numbered from propeptide. R:residue

EIA:Enzyme Immunoassay, WB:Western Blot, IP:Immunoprecipitation
Immunohistochemistry (FS:Frozen Section, PS:Paraffin Section)
Cross-reaction (H:Human, B:Bovine, Rb:Rabbit, r:rat, M:Mouse, G:Guinea pig, S:Sheep, P:Pig )