For Life and Health,
Create New Values with Original Technologies



We develop API manufacturing methods using advanced organic synthesis technologies. We are striving to develop new technology not only using already established methods.

Prostaglandin Products:
We can manufacture prostaglandin derivatives from corey lactone by our original manufacturing methods.

Organic Synthesis Technology:
We can manufacture substances with complex chemical structures or long and difficult synthesis processes under GMP control. Also, safety and environmental influence are considered in our manufacturing processes.
We also have synthesis technologies that use enzyme reactions together with organic synthesis. These methods are epochal to significantly shorten the long and difficult synthesis process and contribute to sustainable manufacturing operations.

Other Synthesis Technology:
We are studying to manufacture several supersulfides, and we have established the manufacturing methods. Supersulfides have various anti-aging and anti-inflammatory effects, and these are getting much attention now.
Also, we have found innovative technologies that plant-derived carbohydrate chain works as a chemical catalyst. We continue applied research for the expression mechanism of catalytic property and bioactivity effects.

Liposome Technology:
We also focus on the cosmetics business. We are working on cosmetics product development for liposome-encapsulated products as the carrier of the drug delivery system (DDS). Also, we analyze and evaluate the effect of liposome-encapsulated products.
We are continuing research to provide products that can solve customer's problem like insoluble, instable, low permeability.

Actual Results

Molecules 2020, 25, 3197-3209.]
Asymmetric amination of meso-epoxide with vegetable powder as a low-toxicity catalyst.
Yuki Takeuchi, Tatsuhiro Asano, Kazuya Tsuzaki, Koichi Wada, and Hiroyuki Kurata

J. Biosci. Bioeng. 2019, 127, 79-84.]
Bioconversion of pyridoxine to pyridoxamine through pyridoxal using a Rhodococcus expression system
Ei-tora Yamamura

Biosci. Biotech. Biochem. 2019, 83, 1124-1135.]
A novel method of producing the key intermediate ASI-2 of ranirestat using a porcine liver esterase (PLE) substitute enzyme
Ei-Tora Yamamura, Kazuya Tsuzaki, Shinji Kita

Biosci. Biotech. Biochem. 2019, 83, 309-317.]
A novel method of producing the pharmaceutical intermediate (R)-2-chloromandelic acid by bioconversion
Ei-Tora Yamamura, Shinji Kita

J. Biosci. Bioeng. 2018, 125, 625-631]
Isolation of two plasmids, pRET1100 and pRET1200, from Rhodococcus erythropolis IAM1400 and construction of a Rhodococcus–Escherichia coli shuttle vector
Ei-tora Yamamura

Biosci. Biotech. Biochem. 2018, 82, 1396-1403.]
Construction of Rhodococcus expression vectors and expression of the aminoalcohol dehydrogenase gene in Rhodococcus erythropolis
Ei-Tora Yamamura

Bull. Chem. Soc. Jpn. 2018, 91, 678-683.]
Catalytic Asymmetric Amination of meso-Epoxide Using Soy Polysaccharide (Soyafibe S-DN)
Yuki Takeuchi, Tatsuhiro Asano, Kazuya Tsuzaki, and Koichi Wada